Cisplatin a549
WebFeb 22, 2024 · Lung cancer is the leading cause of cancer-related death in the Unites States, and approximately 85% of all lung cancers are classified as non-small cell lung cancer (NSCLC), which is extremely difficult to treat and its survival rate is low. After decades of clinical trials, the most effective treatments are still those that implement the … WebSilencing USP14 increased the tumor antagonistic action of DDP in A549 cisplatin-resistant (A549/DDP) cells, while USP14 overexpression decreased the antagonist effects. Aptamer-targeted nano-zinc carriers were loaded with USP14 siRNA to …
Cisplatin a549
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WebWe previously had obtained cisplatin-resistant non-small cell lung cancer (NSCLC) A549 cell lines (A549/DDP) and its parental A549 cells. 12,13 In this study, we aim to observe the difference of autophagy between A549/DDP and A549, and also determine the role autophagy plays and the underlying regulation mechanisms during DDP treatment in … WebNov 19, 2013 · A549 and DU145 cells were exposed to cisplatin at an IC50 dose and ROS levels measured in Annexin V-negative subpopulation as described in Materials and Methods and in Figure S2. Antimycin A was used as …
WebThe A549 cells transfected with sh-PVT1 or sh-NC plasmid were seeded into the right flank of the mice, and 50 μM cisplatin was injected into the intraperitoneal every three days. … WebJan 20, 2024 · Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death . Authors Wen-Jun Liu 1 2 , Peng-Yu Pan 2 , Ye Sun 3 , Jian-Bo Wang 4 , Huan Zhou 2 , Xin Xie 1 , Zhi-Yuan Duan 1 , Han-Yu Dong 2 , Wen-Na Chen 4 , Li-de Zhang 2 , …
WebIn addition, GA reduced the MRP2 and LRP protein expression level in A549/DDP cells. GA inhibits the proliferation, induces cell cycle arrest and apoptosis in A549/DDP cells. Combination of GA with cisplatin enhances the antitumor effects on cisplatin-resistant lung cancer cells by downregulating MRP2 and LRP expression. Webined if clusterin expression affects the cisplatin sensitivity in vivo; A549, A549/sCLU, and A549/pcDNA3.1 cells were injected subcutaneously into the right flank of nude mice. Cisplatin could significantly inhibit the tumor growth in mice injected with A549/pCDNA3.1 scramble cells and A549 cells compared to the mice injected with
WebThe addition of TAS reduced the IC 50 value of cisplatin in A549 and H1299 cells, indicating that TAS can significantly increase the sensitivity of lung cancer cells to …
WebMay 11, 2012 · As shown in Figures 2a and b, apoptosis were induced in both A549 and H460 cells when they were treated with cisplatin alone (10 and 12.45%, respectively), … novatel wireless console port for mifi 5792WebIn addition, GA reduced the MRP2 and LRP protein expression level in A549/DDP cells. GA inhibits the proliferation, induces cell cycle arrest and apoptosis in A549/DDP cells. … how to solve 2 simultaneous odes in matlabWebJan 20, 2024 · The A549/DDP cells were plated at a density of 5 × 10 3 cells per well in a 96-well plate and cultured overnight. Then, the cells were transfected 24 h prior to glutamine deprivation with siRNA-targeting SDHB (stB0007812C, sequence 5’→3’: CCCGAAGGTTGACACCAA) or non-targeting control (RiboBio Technology) using … how to solve 100 cpu usageWebJul 26, 2024 · In A549 cells, cisplatin exposure led to a significantly higher expression of genes coding for proteins mediating G2/M arrest and apoptosis (mouse double minute 2 … how to solve 2 step linear equationsWebOct 1, 2024 · Cisplatin-resistant A549 cells (A549/CisR) were derived from A549 cells by continuous cisplatin treatment. The original parental A549 cells were initially treated … how to solve 2 way tablesWebJan 12, 2024 · To evaluate whether cilastatin influences the antitumor effects of cisplatin in human cancer cells, SCID mice were injected with A549 human lung adenocarcinoma cells. The mice were treated with... how to solve 2x + 5y 10WebTargeted therapy for cisplatin‐resistant lung cancer via aptamer‐guided nano‐zinc carriers containing USP14 siRNA Xinmin Zhao,1 ,2 Xianghua Wu,1 ,2 Huijie Wang,1 ,2 Songtao Lai,2 ,3 ,4 and Jialei Wang1 ,2 Xinmin Zhao 1 Department of Thoracic Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai China 2 Department of Oncology, novatel wireless hspa