WebMar 1, 2024 · Cyclophosphamide induced cerebral neurotoxicity via oxidative inflammation and apoptosis. The Nrf2 signaling was downregulated in rats injected with cyclophosphamide. Sitagliptin exerted inhibitory mechanism against oxidative stress, inflammation and apoptosis in the cerebrum. WebDec 13, 2024 · The neurotoxicity associated with a variety of conventional cytotoxic chemotherapy agents will be reviewed here. The neurologic complications of platinum …
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WebCentral neurotoxicity (including sleepiness, confusion and occasionally hallucinations). Delayed effects: There is a slight risk of developing a blood cancer such as leukemia after taking ifosfamide. Talk to your doctor about this risk. Your fertility, meaning your ability to conceive or father a child, may be affected by ifosfamide. WebSep 18, 2024 · Blood in the urine dizziness, confusion, or agitation fast heartbeat joint pain shortness of breath swelling of the feet or lower legs unusual tiredness or … billy mack - christmas is all around
Cytokine Release Syndrome and Neurotoxicity
WebFeb 24, 2014 · Docetaxel can cause a toxic optic neuropathy possibly due to an ischemic or neurotoxic mechanism at the optic nerve head. With cessation of docetaxel therapy and … WebMar 14, 2024 · MTX is particularly neurotoxic when given at high dosages (≥1 g/m 2) intravenously, when administered at normal dosages intrathecally, or when MTX is … WebNov 1, 1983 · Abstract. cis-Platinum, bleomycin, 5-fluorouracil, and cyclophosphamide were administered to rodent and canine models of osmotic blood-brain barrier modification to evaluate the relationship between tissue drug concentration in brain and the physiological and neuropathological effects of the drug. The toxicity studies were carried out in the … billy mace bonnie and clyde