WebMutations in GATA3 cause variable degrees of hypoparathyroidism, deafness, and kidney disease birth defects because of 1) ... Immuocytochemical analysis of GATA3 protein in … WebNov 23, 2024 · Experimental evidence showed that ZnF2 of GATA3 is required for DNA binding 8,9. 15% of the mutations published in male breast cancer are present in GATA3, with hotspots recorded at residues S308 ...
Role of GATA3 exon 6 germline mutations in breast cancer …
WebSep 13, 2004 · Western blot analysis of GATA3 protein expression. In all, 11 breast tumors, one normal breast sample and the MCF-7 cell line protein extracts were run on a 4–20% SDS–PAGE gel and assayed for ... WebOct 25, 2024 · Upon GATA3 loss-of-function, due to down-regulation or mutation, which occurs frequently in breast cancer (3, 69, 70), the expression of ZEB1 and HDAC2 are derepressed; consequently, elevated ZEB1 and HDAC2 can promote EMT and metastasis. Surprisingly, we found that ZEB1 represses the expression of miR-455-3p through … powerball results january 14 2023
Analysis of the correlation between key gene mutations and breast ...
WebMar 23, 2024 · Breast cancer (BRCA) ... CDH1, and GATA3 mutations were most frequent (>10%) in BRCA, in which missense mutations are common. Among them, the probability of TP53 mutation was exceptionally high in high-risk patients. TP53 is a key tumor suppressor gene, and TP53 expression in noncancerous tissues is closely associated … WebFeb 15, 2024 · Abstract. GATA3 has been identified as one of the most frequently mutated genes in breast cancer. In the METABRIC cohort, among 1,980 patient cases, 230 breast cancers harbored GATA3 mutations (~12%). 75% of the GATA mutations were observed in luminal breast tumors (47% in luminal A, 28% in luminal B). The recent genomic data … In the TCGA-BRCA cohort, tumors of 975/1085 female patients were evaluated for somatic mutations. Among these patients, a total of 103 different GATA3 mutations were identified in 138 patients (14.15%). Insertions constituted the largest type of mutations (50.5%), followed by deletions (29.1%) and … See more The median overall survival was 10.80 ± 0.7 years (11.69 ± 3.63 and 10.61 ± 2.19 years in patients without GATA3 mutation compared with patients with GATA3 mutation, respectively; p = 0.73). There was no … See more To gain an insight into the functionality of the DEGs between normal and tumor (mutant and non-mutant) samples, gene set enrichment … See more According to the TCGA expression data, GATA3 expression level was higher in GATA3-mutant (log FC = 2.78, p = 4.38E−34 in all patients and log FC = 2.66, p = 2.07E−57 in ER-positive subgroup) and non-mutant (log … See more To gain a better understanding of the biological relationships between breast cancer-related genes, the genes that share the same GO … See more powerball results jan 3 2022