WebDec 15, 2024 · Alexander Seiler et al. established an inducible Gpx4 gene knockout mouse model and showed that GPx4 depletion leads to a large amount of lipid peroxidation and cell death [34 ]. Overexpression of GPX4 and gene knockout regulated the lethality of 12 ferroptosis inducers but didn't affect 11 compounds with other lethal mechanisms [ 35]. WebAug 23, 2024 · GCH1 overexpression protects GPX4-knockout cells from ferroptosis, demonstrating that GCH1 is a completely GPX4-independent ... Deik AA, Li H, Eaton JK, Wang W, Tseng Y-Y, Deasy R, Kost-Alimova M, Dančík V, et al. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. Nat …
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WebGpx4 −/− HT1080 cells were grown in DMEM supplemented with 10% FBS, 1% glutamine, 1% penicillin-streptomycin mix, 750 μg/ml neomycin. We found that Gpx4-knockout … WebAug 18, 2024 · The activity of lipid repair enzyme called GPX4 which exerts an antioxidative effect on ferroptotic process depends on the biosynthesis of glutathione (GSH) (5), and is identified as a key regulatory factor in ferroptosis. the orient caulfield south
Frontiers The Mechanisms of Ferroptosis and the Applications in …
WebNov 6, 2024 · However, as mentioned previously, SLC7A11 inhibitor HG106 can induce non-ferroptotic cell death in lung cancer cells, while GPX4 inhibitors appear to induce cancer cell-specific ferroptosis. Nevertheless, further study of the specificity and effects of targeting SLC7A11 or GPX4 in lung cancer in conditional knockout mice is needed. WebJan 7, 2024 · Major finding: Targeting GPX4 induces selective cell death of drug-tolerant persister tumor cells by ferroptosis. Concept: GPX4 knockout suppresses tumor relapse in a xenograft model of melanoma treated with BRAF/MEK inhibitors. Impact: GPX4 inhibition may be a therapeutic strategy to prevent the emergence of drug-resistant tumors. WebAlthough heat shock protein family B (small) member 1 (HSPB1, a member of small HSP) or HSP90 also inhibits or promotes ferroptotic cancer cell death by targeting iron uptaking … the orient cape town