WebNational Center for Biotechnology Information Web9 de set. de 2011 · HIF-1α is regulated by the cellular O 2 concentration and determines the transcriptional activity of HIF-1 . Twist, a basic helix-loop-helix (bHLH) transcription factor, has been known to promote tumor metastasis by …
Direct regulation of TWIST by HIF-1alpha promotes metastasis
Web15 de jul. de 2015 · In addition to Snail, HIF-1 could also regulates the expression of Twist by binding directly to the HRE in the Twist proximal promoter and promote EMT and metastastic phenotypes 51,52. WebThe heterodimeric transcription factor, hypoxia inducible factor-1 (HIF-1), is an important anticancer target as it supports the adaptation and response of tumors to hypoxia. Here, we optimized the repressed transactivator yeast two-hybrid system to further develop it as part of a versatile yeast-based drug discovery platform and validated it using HIF-1. We … library of congress audio books billy budd
Hypoxia-inducing factors as master regulators of stemness …
Web19 de jan. de 2016 · In tumours, HIF-1α promoted the expression of transforming growth factor (TGF)-β, LOX, Snail, TWIST-1, TCF-3, ZEB1 (Zinc finger E-box-binding homeobox … WebThis study aimed to examine HIF-2α, TWIST, and CXCR4 expression in papillary thyroid carcinoma (PTC) and assesses the association of their expression with … WebHow to Do Hip Twists. Part of the series: Getting Fit & Building Strength. When doing a hip twist, you'll be working a great deal on building the muscles in ... library of congress audio books