Ipf muc5b
Web16 aug. 2024 · The study of idiopathic pulmonary fibrosis (IPF) has changed fundamentally over the past few decades with increasing understanding of the role of genetics and genomics in disease risk.1,2 However, many genetic discoveries to date cannot easily be applied in the clinic due to the complexity of inherited risk in this disease. Prognosticating … WebAlthough there have been many studies establishing the association of the MUC5B promoter variant with IPF, this is the first study to demonstrate the contribution of rs35705950 to both MUC5B promoter activity and the distribution of …
Ipf muc5b
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Ondanks uitvoerig onderzoek is de oorzaak van IPF nog steeds onbekend. De fibrose die bij IPF optreedt, wordt in verband gebracht met sigarettenrook, omgevingsfactoren (bijv. beroepsgerelateerde blootstelling aan gassen, rook, chemicaliën of stof), andere medische aandoeningen als oesofageale reflux, of genetische aanleg. Geen van deze factoren geldt echter voor alle mensen met IPF en daarom vormen ze geen volledig sluitende verklaring voor de ziekte. WebMUC5B encodes a highly glycosylated mucin-5B precursor protein (Mucin-5B) that contributes to airway mucus production and is important in maintaining immune homeostasis ( 4, 7, 11 ). Single-nucleotide polymorphisms (SNPs) within TOLLIP and MUC5B have recently been shown to be associated with IPF susceptibility and survival ( 12 – 14 ).
Web27 feb. 2024 · The MUC5B rs35705950 minor allele (T) was more frequent in IPF subjects than in HC (35% vs 9% p < 0.001). TOLLIP SNPs alleles and genotype distribution did … WebOur previous study showed that in adult mice, conditional Nedd4-2-deficiency in club and alveolar epithelial type II (AE2) cells results in impaired mucociliary clearance, accumulation of Muc5b and progressive, terminal pulmonary fibrosis within 16 weeks. In the present study, we investigated ultrastructural alterations of the alveolar epithelium in relation to …
Web31 jul. 2024 · Idiopathic pulmonary fibrosis (IPF) is defined as a chronic progressive type of idiopathic interstitial pneumonias (IIPs) of unknown cause, occurring mainly in elderly, limited to the lungs, and associated with the histopathologic and/or radiologic pattern of usual interstitial pneumonia (UIP) [ 1 ]. WebGenomic investigation of DNA acquired from peripheral blood has identified several common gene variants associated with ILD. The variant with strongest effect is a polymorphism in the promoter region of MUC5B, which encodes a mucin producing gene critical for airway host defense ().The presence of this variant increases the risk of developing IPF by 5-fold …
WebThe MUC5B promoter variant is the strongest known risk factor for the development of IPF, with homozygotes for the polymorphism having a 20-fold increased risk of IPF and heterozygotes having a sevenfold increase in risk.
Web27 feb. 2024 · We confirm that the minor allele of MUC5B rs35705950 is associated with IPF. The minor allele of TOLLIP rs5743890 appears to be a predictor of worse survival and more rapid disease progression, therefore being of potential utility to stratify IPF patients at baseline. Background python 6位随机数Web19 jan. 2024 · Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal fibrotic lung disease that occurs primarily in middle-aged and elderly adults. It is a major cause of morbidity and mortality. With an increase in life expectancy, the economic burden of IPF is expected to continuously rise in the near future. python 7111pWeb12 apr. 2024 · Besides, MUC5B promoter variant rs35705950 is a high-risk factor for IPF 11, the cluster A exhibited higher MUC5B expression than B. These results suggested that cluster A was related to IPF. python 7 9\u0026 2WebTo test whether the MUC5B promoter variant rs35705950 alters the distribution of MUC5B in IPF lung, we performed quantitative histopathological analysis of IPF lung tissue using … python 7145pWebIdiopathic pulmonary fibrosis (IPF) is a chronic, debilitating, fibrotic lung disease leading to respiratory failure and ultimately to death. Being the prototype of interstitial lung … python 7.0Web1 jun. 2015 · While the rs35705950 MUC5B SNP was associated with increased MUC5B mRNA expression in lungs of control subjects, MUC5B expression was uniformly … python 7.3WebFor IPF patients with DSP alleles and MUC5B alleles, the mortality rate is lower, and anti-fibrosis drugs are more effective in treatment (Doubkova et al., 2024). python 7254p