WebNov 5, 2024 · Leber hereditary optic neuropathy (LHON) is a rare disease with a prevalence of 1 in 25,000 births. LHON usually presents in young males, with painless loss of visual acuity in one or both eyes. Recently an autosomal recessive form of the disease (arLHON or LHONAR) has been described, which is caused by a biallelic mutation in the DNAJC30 … WebFigure 2. (A) In eQTL analysis, gene expression is treated as a quantitative phenotype and genetic loci controlling the phenotypic changes can be identified based on correlations between the genomic variations and expression profiles from the same set of samples.(B) A current flow network algorithm can be used to prioritize the candidate disease causing …
Biological Disease Mechanism Networks SpringerLink
WebJan 1, 2024 · We constructed the phenotypic disease networks in IHD and control patients and further assessed differences in comorbidity patterns. The community detection … WebOct 3, 2024 · Step 1: for each disease, DISNOR extracts ‘seed’ genes (from DisGeNET); step 2: seed genes are used to query the SIGNOR knowledge base to extract causal … filepath 0
A Dynamic Network Approach for the study of human phenotypes
WebPhenotypic Disease Networks (PDNs). Nodes are diseases and links are correlations. Node colour identifies the diseases based on the ICD9 category. Only statistically significant … WebApr 1, 2024 · A new phenotypic database summarizing correlations obtained from the disease history of more than 30 million patients in a Phenotypic Disease Network (PDN) is introduced, offering the potential to enhance the understanding of the origin and evolution of human diseases. 565 PDF The human disease network WebNov 9, 2024 · To apply the phenotypic hierarchical network, phenotypic co-occurrence relationship, and disease-phenotype differential network to the diagnosis of rare diseases, we developed a web platform based on Node.js, … file patched successfully