WebIndications. Early Breast Cancer PHESGO TM (pertuzumab, trastuzumab, and hyaluronidase-zzxf) is indicated for use in combination with chemotherapy for. the neoadjuvant treatment of adult patients with HER2-positive, locally advanced, inflammatory, or early stage breast cancer (either greater than 2 cm in diameter or node-positive) as part … WebApr 15, 2024 · Abstract. On June 29, 2024, the FDA approved pertuzumab, trastuzumab, and hyaluronidase-zzxf subcutaneous injection (Phesgo) for the treatment of patients with HER2-positive early-stage and metastatic breast cancer. Patients should be selected for therapy based on an FDA-approved companion diagnostic test. Approval was primarily …
Phesgo - FDA prescribing information, side effects and uses
WebDec 21, 2024 · Prior to administration, withdraw entire contents of drug from vial using a syringe and transfer needle. Remove transfer needle and replace with a 25- to 27-gauge, 3/8–5/8-inch hypodermic needle; adjust volume of drug solution in syringe to 15 mL for the initial dose or 10 mL for maintenance doses. Administer sub-Q injection immediately into … WebPhesgo® combined these two separate monoclonal antibodies into a single injection for use. Trastuzumab and pertuzumab are monoclonal antibodies that both target a protein called HER2 on cancer cells; however, they bind to different sites on the protein. When bound, these agents work together to inhibit cancer cell growth and cause cancer cell ... football game day poster ideas
Pertuzumab: Uses, Interactions, Mechanism of Action
WebOct 13, 2024 · What Is Phesgo? Phesgo (pertuzumab, trastuzumab, and hyaluronidase-zzxf) is a combination of HER2/neu receptor antagonists and an endoglycosidase indicated for use in combination with chemotherapy as neoadjuvant treatment of patients with HER2-positive, locally advanced, inflammatory, or early stage breast cancer (either greater than … WebAug 8, 2024 · Phesgo contains a combination of hyaluronidase, pertuzumab, and trastuzumabis. Phesgo is a cancer medicine that is used alone or with other medicines to … WebTo evaluate the efficacy of Phesgo plus giredestrant compared with Phesgo; ... In addition to its direct antagonist properties, the mechanism of action of giredestrant includes reducing levels of ER protein through proteasome-mediated degradation. Degradation of ER is hypothesized to enable full suppression of ER signaling, which is not ... football game day songs