Web(mCD14) and the serum soluble 48–56 kDa (sCD14, an acute phase protein).4 Soluble CD14 found in human serum has been attributed to the shedding of mCD14 from monocytes, macrophages and PMN. Membrane CD14 as a receptor for lipopolysaccharide (LPS) on the membrane of the mononuclear phagocyte (MPS) binds to LPS-binding protein (LBP) WebCD14 exists in two forms. It is either anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble …
Targeting innate immunity by blocking CD14: Novel approach to …
WebFeb 23, 2004 · Use of soluble CD14 (sCD14) for the manufacture of a medicament for therapeutic or preventive treatment of a disease involving a chronic inflammation condition and a clinical disorder associated with insulin resistance in an animal or a human. Examples of diseases include type 2 diabetes mellitus, obesity, metabolic syndrome, arteriosclerotic … WebJun 27, 2014 · cd14在人体内有两种存在形式:膜结合型cd14(mcd14)和可溶性cd14(scd14)。 mCD14主要通过糖基磷脂酰基酶(Glycosylphosphatidylinositol,GPI细胞以及树突状细胞等髓样细胞表面;sCD14GPI结构,主要是把LPS信号传导给mCD14阴性细胞,如内皮细胞、上皮细胞等,介导这些细胞对内毒素的应答反应。 famous people with estp personality
Applied Microbiology and Biotechnology
WebSep 1, 2010 · An increase in sCD14 levels are likely to be dependent on either shedding of mCD14 through cleavage from myeloid cells or, possibly, from secretion of sCD14 … http://www.diaclone.com/p-663 WebJun 3, 2024 · Background Early diagnosis of bacterial sepsis in neonates is hampered by non-specific symptoms and the lack of rapid responding laboratory measures. The … copy paste screen shortcut keys